China stops research into gene-editing after 'CRISPR baby'

The Chinese government on Thursday ordered a temporary stop to all scientific research related to the editing of human genes — the latest condemnation following claims by Chinese scientist He Jiankui that he had genetically altered twin babies.

Beijing also warned that He's gene-editing activities may have broken the law and ordered an investigation. 

Government condemnation

• China's science and technology vice minister, Xu Nanping, described He's behavior as "shocking and unacceptable" in an interview with state broadcaster CCTV.
• The ministry "firmly opposes" the experiment and has "already demanded that the relevant organization suspend the scientific activities of relevant personnel," Xu said.
• The National Health Commission has ordered an investigation into He's claims, as has the Southern University of Science and Technology, where the scientist worked.
• The organizers of a Hong Kong biomedical conference, where He announced his gene-editing claims, described his work on Thursday as "deeply disturbing" and "irresponsible."

Read more:  Opinion: Why we should stop human gene editing

How we got here

• He claimed on Monday that he had changed the genetic material of two twin embryos to make them resistant to HIV.
• Scientists from around the world immediately condemned He for his alleged activities and called for standards to be put in place regarding genetic modification.
• On Wednesday at the biomedical conference He said he was "proud" of his work, even as criticism continued to pour in.
• He was expected to speak Thursday at the conference but did not attend.

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Constroverisal application and procedure

• He's claim of producing the world's first genetically modified babies has not been independently verified.
• His supposed application of the gene-editing technology, called CRISPR, is ethically controversial and its potential related effects remain unclear.
• He's filing to a clinical trials database shows that a hospital did an ethical review of the project, but the hospital in question denied ever discussing the work.
• He released his work via YouTube, bypassing the usual channels of review for scientific work 
• Scientistics condemned He for his failure to adhere to research standards, with the conference organizers citing "inadequate medical indication, a poorly designed study protocol, a failure to meet ethical standards for protecting the welfare of research subjects, and a lack of transparency in the development, review and conduct of clinical procedures." 

cmb/msh (AFP, Reuters)

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